IV Anesthetic Agents PK-PD Simulator v3.0

License: GNU GPL v3. Copyright (C) [2026] [Prof. Jyotirmay Kirtania]

Anaesthetic Agent

Patient Reference

Weight (kg)

Age (yr)

Population mean PK shown. No covariate adjustment.

Initial Bolus (T = 0)

Dose (mg)

mg/kg

2.14

Repeat Boluses

Dose (mg)

At T (min)

Infusions

Rate input

Units

Weight-normalized infusion is converted internally to mg/min using current body weight.

Start

Stop

Display Options

Target Ct (mcg/mL) — 0 to hide

Threshold overlay mode

Approximate reference ranges only. Not patient-specific validated targets.

Show threshold bands

Apply age scaling where literature exists (propofol only)

Uses limited Schnider age terms on V2 and CL2 only; not full covariate adjustment.

Opioid coadministration modifier (propofol only)

Shifts BIS-oriented propofol reference bands downward by ~20% for visual teaching only.

Simulation duration (min)

Cp — Plasma

Ce — Effect Site

Ct — Target

Bolus

Infusion

>PROPOFOL

Peak Cp

—

Peak Ce

—

Duration ≥ LOC

—

min above threshold

Recovery (Ce < sedation)

—

min from T₀