AA-PKPD-Sim-v1.2 | Inhaled Anaesthetic Agent Pharmacokinetics Pharmacodynamics Simulator | License: GNU GPL v3.0, Copyright (C) [2026] [Prof. Jyotirmay Kirtania]

4-compartment · RK4 · Age-corrected MAC · BIS · 0–12 h Sevoflurane

Agent

Carrier Gas

Patient & Dose

Age (years)40

Target (× MAC)1.00 ×

FGF (L/min)2.0

Duration (h)4

Pharmacokinetics

MAC at age—

Target FI (vol%)—

λ blood:gas—

VRG t½—

Weight (kg)70.0

CO (L/min)5.60

VA (L/min)4.55

FRC (L)2.45

Pharmacodynamics (BIS)

BIS (steady state)—

Anaesthetic state—

t → 1 MAC brain—

Alveolar Uptake — FA/FIPK

Tissue Distribution (MAC equiv.)PK

Bispectral Index (BIS)PD

Alveolar Concentration (vol%)PK

PK PD Model References: Eger EI II (1963–1994) · Mapleson WW, Br J Anaesth 1996;76:179 (MAC age) · Nickalls & Mapleson, BJA 2003;91:170 · Lerman J (1984,1994; paediatric MAC) · Yasuda N, Anesth Analg 1989;68:791 (partition coefficients) · Goto T et al, Anesthesiology 1998;89:867 (xenon) · Vanluchene ALG, Anesthesiology 2004;100:292 · Cederholm I, Acta Anaesth Scand 2000 (N₂O BIS) · Model: 4-compartment VRG/MG/FG/VPG · RK4 Δt=0.25 min · Circle-system wash-in model. IMPORTANT NOTE: This is a mechanistic teaching model based on classical compartmental theory. It uses simplified assumptions and should not be used for clinical decision-making.